Biomedical Research Projects

At the core of CBORT's cutting-edge OCT innovation are interactive collaborations that motivate the development of new technologies. Currently, we have several ongoing projects that provide well-defined technical challenges, addressed by our Technical Research and Development (TRD) that will yield significant advances in biomedicine when overcome.

Integrative Pathophysiology of Solid Tumors

Investigators: Dai Fukumura, PhD & Rakesh Jain, PhD

Summary: The goal of this project is to develop strategies to overcome physiological barriers to the delivery of molecular and cellular medicine in solid tumors. The resource technologies developed at CBORT will aid in the study of tumor microvasculature in vivo.

Source of Funds: National Cancer Institute, National Institutes of Health

Advanced Imaging for Glaucoma

Investigators: David Huang, MD, PhD

Summary: The goal of this project is to improve the detection of glaucoma and the measurement of its progression using OCT, an imaging technology that is capable of measuring retinal degeneration with microscopic resolution. The resource technologies developed at CBORT will provide high-resolution and high-speed imaging equipment for ophthalmic imaging.

Source of Funds: National Eye Institute, National Institutes of Health

Structure and Function Relations in Middle Ears

Investigators: John J. Rosowski, PhD

Summary: The goal of this project is to understand the consequences of structural variations and alterations on middle-ear function in models of hearing and ear disease. The resource technologies developed at CBORT will provide tools to perform quantitative analyses to understand variation in hearing function that result from phylogenetic, developmental, and pathological differences in middle-ear structure and function.

Source of Funds: National Institute on Deafness and Other Communications Disorders, National Institutes of Health

Natural History of Vulnerable Coronary Plaques

Investigators: Sergio Waxman, MD & Giora Weisz, MD, Evelyn Regar, MD and Atsushi Tanaka, MD, PhD

Summary: The goal of this project is to investigate the natural history of vulnerable plaques and determine the morphologic predictors of AMI. The resource technologies available will provide a technique that is capable of identifying vulnerable plaques in the coronary arteries of living patients.

Source of funds: National Heart Lung and Blood Institute, National Institutes of Health

Point-of-Care Microfluidics for Early Detection of Cancer

Investigators: Mehmet Toner, PhD & Daniel Haber, MD, PhD

Summary: The goal of this project is to develop microfluidics to capture rare circulating tumor cells (CTCs) from patient blood samples. Identification and isolation of CTCs could potentially provide a powerful tool for early detection of cancer and become a widespread application for population screening.

Source of Funds: National Institute of Biomedical Imaging and Bioengineering